| Week 2 8/31/18 | |||
| Midland Empire Conference | |||
| *Chillicothe | Harrisonville | ||
| at Kirksville | at *Maryville | ||
| *Savannah | *KC St Pius | ||
| at Pleasant Hill | at St Michael | ||
| KC Center | *Benton | ||
| at *Lafayette | at Excl Springs | ||
| East Buchanan | *Cameron | ||
| at *LeBlond | at KC East | ||
| Area Games | |||
| Monroe City | Lexington | ||
| at Brookfield | at Trenton | ||
| Hamilton | Carrollton | ||
| at Gallatin | at Westran | ||
| Polo | Marceline | ||
| at Slater | at Knox County | ||
| Mark Twain | |||
| at Milan | |||
| 8-Man | |||
| Pattonsburg | Orrick | ||
| at Braymer | at Norborne | ||
| Southwest Ludlow | |||
| South Holt | |||
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